Programmable reactivity-based one-pot oligosaccharide synthesis
نویسندگان
چکیده
منابع مشابه
Reactivity-based one-pot total synthesis of fucose GM1 oligosaccharide: a sialylated antigenic epitope of small-cell lung cancer.
The total synthesis of the sialic acid-containing antigenic epitope fucose GM(1) (Fuc-GM(1)) by an improved reactivity-based one-pot synthetic strategy is reported. Based on a thioglycoside reactivity database, three saccharide building blocks, 3, 4, and 5, were designed and prepared to incorporate a descending order of reactivity toward thiophilic activation. Using the reactivity-based one-pot...
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ژورنال
عنوان ژورنال: Nature Protocols
سال: 2006
ISSN: 1754-2189,1750-2799
DOI: 10.1038/nprot.2006.489